Self-adjusting synthetic gene circuit for correcting insulin resistance
نویسندگان
چکیده
منابع مشابه
Self-adjusting synthetic gene circuit for correcting insulin resistance
By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functionally rewiring the mitogen-activated protein kinase (MAPK) signalling pathway to produce MAPK-media...
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ژورنال
عنوان ژورنال: Nature Biomedical Engineering
سال: 2016
ISSN: 2157-846X
DOI: 10.1038/s41551-016-0005